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1. Chromium - Health Professional Fact Sheet. NIH Office of Dietary Supplements, 2022.Updated June 2, 2022. Adequate Intake: 35 mcg/day men 19-50, 25 mcg women 19-50 (30 and 20 mcg after 50). No upper limit set. A 2019 overview of eight meta-analyses (58 trials, 3 weeks to 6 months, 1.28 to 1,000 mcg/day) found chromium lowered fasting glucose and A1C slightly in people with diabetes, with unclear clinical importance. A 24-week trial in 137 adults with type 2 diabetes at 1,000 mcg/day picolinate found no significant effect on A1C or fasting glucose. The ADA (2010) did not recommend chromium and its 2015 statement found evidence insufficient for routine use; FDA allows one qualified claim on chromium picolinate and insulin resistance, which it calls highly uncertain. About 1.2% of chromium from picolinate is absorbed. Case reports link supplements to hypoglycemia, kidney, liver and other problems. May add to insulin and metformin effects (hypoglycemia risk) and may lower levothyroxine absorption. Chromium-only products usually give 200 to 500 mcg.
2. Questions and Answers on Dietary Supplements. U.S. Food and Drug Administration, 2026.Content current as of August 27, 2026. FDA enforces supplement rules mostly after products reach the market; it does not approve supplements or their labeling beforehand, does not routinely analyze their content, and FTC handles advertising. Structure/function claims need substantiation and the label disclaimer: This statement has not been evaluated by the Food and Drug Administration; not intended to diagnose, treat, cure, or prevent any disease. Only drugs may make those claims. Report problems through the Safety Reporting Portal.
3. Health Products Compliance Guidance. Federal Trade Commission, 2022.Published December 20, 2022; replaces the 1998 supplement advertising guide; business guidance, not binding law. Health claims generally need competent and reliable scientific evidence, and human randomized controlled trials are what experts generally expect. Animal or test-tube studies alone are not enough. A testimonial is not a substitute for scientific evidence; atypical results need a clear statement of typical results, and results not typical alone does not cure the deception. Material connections such as payment must be clearly disclosed.